| Thu, Sep 17 |
| Detroit @ Buffalo -5.5 | H |
| Sun, Sep 20 |
| Minnesota @ Chicago -4.5 |
| Cincinnati @ Houston -2.5 |
| Jacksonville @ Denver -2.5 |
| Seattle -3.5 @ Arizona |
| Washington @ Dallas -3.5 |
| Indianapolis @ Kansas City -6.5 |
| Mon, Sep 21 |
| New York (G) @ Los Angeles (R) -7 | H |